FDA study finds hidden synthetic ingredients, poor quality control in bitter orange supplements - NutraIngredients-usa.com

The recent study was published in the journal Drug Testing & Analysis​.  It was conducted by researchers in FDA’s Center for Food Safety and Applied Nutrition (CFSAN).  

In the study the researchers purchased 59 products that were labeled as containing ‘bitter orange,’ whether it was purported to be the primary active ingredient or as part of a broader formula.  Some of the products were suggested for inclusion in the study by the Office of Dietary Supplement Programs while others were discovered and purchased as a result of a simple internet search.

Bitter orange (Citrus aurantium​), also commonly known as Seville Orange, is a citrus species native to eastern Africa and Southeast Asia that has been cultivated in the Mediterranean region and in the United States.  The astringent, bitter unripe fruit has been used as a digestive aid in some traditional medicinal systems. 

Bitter orange benefited from ephedra ban

The researchers noted that bitter orange extracts have gained popularity in the marketplace after the ephedra ban.  Formulators often use these ingredients for their purported thermogenic qualities in products targeted toward weight management and sports nutrition.

The researchers subjected the products to a novel analysis.  One of the purposes of the study was to develop and validate a fast and accurate LC-MS/MS method to detect and quantify five natural phenethylamines present in the botanical (synephrine, octopamine, tyramine, N​-methyltyramine and hordenine) and four synthetic phenethylamines that have been found in products in the marketplace. Those are phenylephrine, methylsynephrine, etilefrine and isopropyloctopamine.

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June 17, 2020 at 09:45PM
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FDA study finds hidden synthetic ingredients, poor quality control in bitter orange supplements - NutraIngredients-usa.com
"ingredients" - Google News
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